Frequently Asked Questions:

Q – What is ProArgi-9 Plus

A – ProArgi-9 Plus is a unique and clinically proven L-arginine Complexer designed to repair the endothelial cells that line all of your cardiovascular system to improve their ability to create nitric oxide which is the master signaling molecule of your cardiovascular system.  The following video will provide you with a quick overview of this product from Synergy WorldWide:

Q – What are endothelial cells and why are they important?

A – Sometimes referred to as the endothelium, your endothelial cells line all of your cardiovascular system.  Because it’s only 1 cell thick many scientists thought it was just an inert membrane whose only function was to keep your blood in your blood vessels.  Research over the last 25 years has shown the endothelium to be an active, multifunctional organ that plays a vital role in metabolic, immunologic, and cardiovascular health.  Scientists now believe that your endothelial cells ultimately determine the health of your blood vessels and play a major role in preventing cardiovascular disease.

Q – What is this nitric oxide that the endothelial cells produce and how does it benefit me?

A – Nitric oxide is so critical to your cardiovascular health that the 1998 Nobel Prize in Medicine was awarded to three American researchers who discovered how the endothelial cells produce this gas to regulate the vascular walls of your entire cardiovascular system.  Since its discovery much has been learned about the role nitric oxide plays in your overall health and wellness.  For example nitric oxide:

These are just some of the benefits of nitric oxide.  According to Nobel Laureate Dr. Louise J. Ignarro from his 2005 National Bestseller entitled NO More Heart Disease:

“Nitric oxide is the body’s natural cardiovascular wonder drug.”

Q – How much of ProArgi-9 Plus do I need to take to see a benefit?

A – The amount of the product varies according to your health needs.  To help you better understand this we have create a video that answers this question as well as several others like:

Q – Is this product approved by the FDA?

A – Because this product is a nutritional supplement it is not approved by the FDA since their approval only applies to drugs.  All the ingredients in ProArgi-9 Plus are natural ingredients that are manufactured with exacting specifications and controls so that you have a pharmaceutical grade quality product.

Q – If the ingredients are natural can’t I just buy them individually at a health food store?

A – Yes, you could take this approach.  In fact, back when Dr. J. Joseph Prendergast (the product formulator) first began to incorporate integrative L-arginine therapy into his practice that is what he did.  He would give his patients a list of ingredients to go buy at the health food store and fix up their own product.  What he found was lack of compliance. So he began to formulate his own product which improved compliance, and also cost less than buying each ingredient separately.  That process has been significantly refined so that ProArgi-9 Plus represents the best combination of heart healthy ingredients to properly support the endothelial cells and their ability to produce nitric oxide.

Q – I’ve read some literature that questions L-arginine and its benefits. True?

A – Yes, there are a few studies that have questioned the use of L-arginine.  It usually centers on the form of L-arginine used since this is a tricky molecule to work with.  Plus, it can have some negative side effects if not brought into your body properly.  That’s why it’s always important to ask who the L-arginine formulator is, and do they have any clinical data to back up the effectiveness of their product.  ProArgi-9 Plus has both. Additionally, ProArgi-9 Plus combines L-arginine with L-citrulline, and other heart healthy ingredients.  This makes a significant difference in helping the endothelial cells produce nitric oxide.  Dr. Louis J. Ignarro, who with 2 other American researchers won the 1998 Nobel Prize in Medicine for the discovery of Nitric Oxide, would also echo the need to combine L-arginine with L-citrulline to improve its benefit.

Q – Are there any side effects associated with ProArgi-9 Plus?

A – No, there are no known negative side effects associated with ProArgi-9 Plus.

Q – Are there any drug interactions?

A – No, since all the ingredients are natural.  With that being said, if you are on medications then you should work with a qualified health practitioner so that medication levels can be properly adjusted as the ProArgi-9 Plus helps your endothelial cells improve in their ability to produce nitric oxide.

Q – What are the ingredients of ProArgi-9 Plus and what do they do?

A – We’ve prepared a special 30 minute webinar to help answer this question. This presentation will provide you with detailed information on ProArgi-9 Plus and all the areas it has been clinically shown to improve.  Please click on:

Webinar Presentation

(Please note that the webinar presentation is 30 minutes long. Once you click on the arrow to start it, please give it 10-15 seconds to load. The remaining time is used to answer questions from those attending.)

For those who don’t have time to watch the webinar here is a quick overview of the key main ingredients:

L-Arginine – This amino acid is the primary ingredient in ProArgi-9 Plus.  It’s used by the endothelial cells to create nitric oxide.  Most research indicates that for you to receive a therapeutic effect you need to consume 5 grams of pharmaceutical grade L-arginine.  This means the quantity and quality of L-arginine used is extremely important.

L-Citrulline – This amino acid is very hard to obtain from food alone so supplementation is the best option.  Most vascular researchers will tell you that L-citrulline is equally important, maybe even more important, then L-arginine because it significantly extends the ability of the endothelial cells to properly produce nitric oxide.  This extended window of improved nitric oxide production allows for significant health benefits. Additionally, L-citrulline can bypass the destructive nature of the arginase enzyme by providing an alternative pathway for the endothelial cells to convert L-citrulline to L-arginine for nitric oxide production.  This is especially important for African Americans since they have a genetic predisposition for carrying higher levels of arginase in their bloodstream.

Vitamin D3 – There is a lot that can said about vitamin D3; from its role in proper calcium balance, to its role in insulin secretion, to immunity factors, and blood pressure regulation.  Bottom line, vitamin D3 helps to maintain the integrity of the entire cardio-metabolic system.

Resveratrol – This red wine extract is high in antioxidants which helps protect the heart and reduces LDL oxidation caused by bad cholesterol.

Folic Acid – This essential B vitamin is extremely important in cardiovascular health.  It is critical to the proper formation of red blood cells and their ability to carry oxygen.

Pomegranate Fruit Concentrate – Pomegranate contains superior antioxidants to inhibit LDL oxidation, support arterial wall strength, and enhance the activity of eNOS, the enzyme responsible for converting L-arginine to nitric oxide.

Vitamin K2  - This vitamin keeps calcium in the bones and out of the arteries.
d-Ribose – Ribose is a naturally occurring sugar that has been extensively studied for its ability to enhance the recovery of energy compounds in heart cells.

Q – How is ProArgi-9 Plus different from other nitric oxide enhancing supplements?

A – While there are many nitric oxide supplements in the marketplace none have the comprehensive long-term and short-term clinical studies clearly demonstrating the effectiveness of this product in helping with cardiovascular issues. From the 15 plus years of actual clinical experience through Dr. J. Joseph Prendergast, the product formulator, to the most resent clinical study at the High Desert Heart Institute, this product has an amazing success ration in helping people with circulatory issues.

Since 1991, Dr. Prendergast has been personally using L-arginine and recommending it to his patients.  He’s been incorporating cutting edge vascular research done in the lab into actual patient care.  True clinical application that has benefited over 7,000 of his patients and tens of thousands of people worldwide.  Dr. Prendergast’s clinical application of proper L-arginine/L-citrulline therapy has resulted in less than 1% patient hospital admissions in 17 years. This is a phenomenal record especially when you realize that 80% of his patients are diabetics who typically have hospital admissions for cardiovascular issues.  Because of this remarkable record the American Diabetes Association awarded Dr. Prendergast the Father of the Year Award in 2008.

Recently ProArgi-9 Plus was used in the most complete and comprehensive human clinical trial ever done on a nutritional supplement.  It was the High Desert Heart Institute Study in which 33 congestive heart failure patients used 4 scoops of ProArgi-9 Plus on a daily basis. Prior to the study these patients were all pharmaceutically and medically managed to the maximum.  60% where waiting for a new heart.  These were very sick people.  By the end of 90 days all were off of the heart donor program.  All were either substantially reduced or off all medications. The results were remarkable.

Q – Will this product help in other areas of health?

A – Definitely!  The ProArgi-9 Plus was originally designed to reverse the oxidative stress on the endothelial cells to prevent and reverse atherosclerosis and the complications from diabetes.  As more people have used the ProArgi-9 Plus for cardiovascular health issues, they are seeing side benefits such as improved cognitive function, reduction or elimination of pain from arthritis, improved renal function, improved peripheral circulation, substantial reduction or complete elimination of hot flashes and night sweats associated with peri menopause, and overall feelings of better health and wellness.

Q – Can athletes see benefits from ProArgi-9 Plus?

A – Absolutely!  ProArgi-9 Plus will improve blood flow to the working muscles allowing you to work at a higher aerobic level with less lactic acid production.  This will allow you to recover quicker so that additional exercise sets can be performed at a higher intensity.  The result will be better muscular development and better cardiovascular function resulting in improve performance.

Q – One of the videos talked about an anti-aging component to ProArgi-9 Plus.  Could you explain this?

A – If taken 30 minutes before bedtime and/or 30 minutes prior to a workout, the L-arginine can naturally cross the blood brain barrier to stimulate the pituitary gland to naturally produce growth hormone.  This aids athletes in muscle development.  It also aids people during their sleep phase since this is when the body repairs itself allowing for an anti-aging effect.  However, those taking this product 30 minutes prior to sleep my find a variety of responses from improved sleep, to deeper sleep, to more vivid dreams, to poor sleep because they have too much energy.  Each person will need to find out for themselves how this product will effect their sleep when taken 30 minutes prior to bedtime.

Q – How can I purchase ProArgi-9 Plus?

A – You can order ProArgi-9 Plus directly from this website page.  Try it with a 100% Satisfaction Guarantee!  Use the  “Click Here to Order” button below!  I’ll even include FREE Shipping* on all US orders.